Volume 2 Issue 4
Characterization of Secondary Autoimmune Etiologies Related to Rheumatic Fever
Mesquita, J.O.#, Machado, A.R.# Del Sarto, R.P., Martins, A.M.A*
The rheumatic fever (RF) is a systemic inflammatory autoimmune disease, which occurs after a pharyngeal infection by Streptococcus pyogenes. The disease can cause arthritis, erythema marginatum, subcutaneous nodules, carditis and Sydenham’s chorea. The signs and symptoms of the disease are caused by the immune response against Streptococcus sp., however, only individuals with a genetic predisposition may be affected by this disease. It was noted in some cases, where the person with RF also have positive diagnostic of other autoimmune diseases such as systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and Hashimoto’s thyroiditis (HT).
Requirement for JNK1 in OVA-induced Airway Hyperresponsiveness in vivo
Junya Onuki, Eiko Takada, Masae Furuhata, Katsuko Sudo, Kuniaki Shimo and Junichiro Mizuguchi*
Bronchial asthma is a chronic inflammatory disease characterized by airway hyperreactivity (AHR) and inflammatory cell infiltration of the airway. c-Jun N-terminal kinase 1 (JNK1), a member of the mitogen-activated protein kinases, is activated by a variety of stimuli including environmental stress and cytokine(s) and plays a crucial role in the induction of inflammation. To assess the role of JNK1 in the induction of bronchial asthma, we examined the production of AHR, inflammatory reaction, and cytokine production using an ovalbumin (OVA)-induced airway inflammation model.